Development of functionalized biomaterials designed to provide physical and chemical cues in a biological environment
Multifunctional polyesters and polyurethanes with peptide-like pendant functional groups
The key transmitter of information between cells and their surroundings is the extracellular matrix (ECM) and this information is processed by specific binding and signaling events between cells and the components of the ECM. Although synthetic biomaterials are being explored for an increasing number of clinical biomedical needs, the ability of current biomaterials to provide the required specificity in binding and signaling is still in its infancy due to the complexity in balancing the material parameters of functionality, reaction feasibility, degradability, hydrophilicity etc. The Joy Lab has developed a modular platform of multifunctional polyesters and polyurethanes to bridge this performance gap between natural polymers such as collagen and synthetic polymers such as PLGA. The platform we have developed is capable of carrying several different functional groups and hence the physical, chemical and potentially biological properties of these polymers can be tailored by the identity of the pendant functional groups. Much like a ‘Lego’ building set, different functional pendant groups can be combined during in the synthetic process to optimize the polymer for the given application. We are currently exploring the utility of such polyesters and polyurethanes for several applications such as wet adhesives, controlled release matrices for protein and small molecule therapeutics, antimicrobials, protein receptor inhibitors, matrices for stem cell differentiation etc.
- S. Gokhale, Y. Xu, A. Joy; A library of multifunctional polyesters with ‘peptide-like’ pendant functional groups; Biomacromolecules, 2013, 14, 2489
- Y. Xu, C. Peng, S. Gokhale, A. Joy; Densely functionalized biodegradable polymers; invited book chapter, Ed. C. C. Chu (New developments in biodegradable polymers, NOVA)